What kind of interaction is it?

Caution: an interaction that may reduce efficacy or raise side-effect risk and warrants monitoring.

Is this interaction backed by published research?

Yes. NutriStack lists 2 citation rows for the Nifedipine + Resveratrol pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Interaction databaseSupplement × PrescriptionReviewed May 2026

Nifedipine and Resveratrol, a caution.

Q: Can I take Nifedipine and Resveratrol together?

Possibly, but with caution. Nifedipine and Resveratrol have a documented caution-tier interaction. Resveratrol inhibits CYP3A4 and intestinal P-glycoprotein, and in rats it raised nicardipine AUC 111-126% via both mechanisms. Because nifedipine shares CYP3A4-mediated clearance and dihydropyridine-class side effects, co-administration with high-dose resveratrol supplements is likely to increase plasma nifedipine, producing more flushing, headache, hypotension, and reflex tachycardia.

Q: How does this affect a NutriStack Stack Score?

-5 to your Stack Score per scored caution row.

Resveratrol inhibits CYP3A4 and intestinal P-glycoprotein, and in rats it raised nicardipine AUC 111-126% via both mechanisms. Because nifedipine shares CYP3A4-mediated clearance and dihydropyridine-class side effects, co-administration with high-dose resveratrol supplements is likely to increase plasma nifedipine, producing more flushing, headache, hypotension, and reflex tachycardia.

2 primary source citations. Emerging evidence. Last verified May 30, 2026.

Open the interaction checker →Read the methodology

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

Sourcing standards·Evidence tiers

From the interaction database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.

At a glance

Substances: Nifedipine and Resveratrol
Pair type: Caution
Evidence (highest tier): Emerging
Source citations: 2 sources
Stack Score effect: −5 to your Stack Score (per scored caution row).
Scope: Supplement × Prescription
Last verified: May 30, 2026

Caution · Emerging evidence

Caution

What is happening. Resveratrol inhibits CYP3A4 and intestinal P-glycoprotein, and in rats it raised nicardipine AUC 111-126% via both mechanisms. Because nifedipine shares CYP3A4-mediated clearance and dihydropyridine-class side effects, co-administration with high-dose resveratrol supplements is likely to increase plasma nifedipine, producing more flushing, headache, hypotension, and reflex tachycardia.

Mechanism. Resveratrol is a mechanism-based CYP3A4 inhibitor and reduces P-gp efflux of dihydropyridines. The combined effect raises oral bioavailability and slows hepatic clearance of nifedipine.

Recommendation. Avoid high-dose resveratrol supplements while on nifedipine. If used, separate doses by at least 4 hours, monitor blood pressure for 2 weeks after starting, and reduce or stop resveratrol if you develop flushing, headache, or readings below your usual range.

Minimum separation. 240

Sources (2)

Stack Score

How this pair moves the number.

Effect on the composite score

If both Nifedipine and Resveratrol are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

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