NutriStack
Quercetin and Resveratrol, a synergy.
Quercetin inhibits resveratrol glucuronidation, increasing resveratrol bioavailability. Both are polyphenol antioxidants with complementary targets.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Quercetin and Resveratrol
- Pair type
- Synergy
- Evidence (highest tier)
- Emerging
- Source citations
- 1 source
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Emerging evidence
Synergy
What is happening. Quercetin inhibits resveratrol glucuronidation, increasing resveratrol bioavailability. Both are polyphenol antioxidants with complementary targets.
Mechanism. Quercetin inhibits SULT1A1 and UGT1A enzymes that conjugate and inactivate resveratrol, increasing its plasma half-life. Both activate SIRT1 and AMPK through different binding sites.
Recommendation. Take together. Quercetin may increase resveratrol bioavailability by inhibiting sulfotransferases and glucuronidases that metabolize resveratrol.
Sources (1)
- De Santi C et al. Sulphation of resveratrol, a natural compound, and inhibition of resveratrol sulphotransferase. Xenobiotica. 2000
Stack Score
How this pair moves the number.
Effect on the composite score
If both Quercetin and Resveratrol are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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