NutriStack
Curcumin Phytosome and Quercetin, a synergy.
Both are potent anti-inflammatory polyphenols that modulate NF-κB and COX-2 through complementary mechanisms.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Curcumin Phytosome and Quercetin
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 1 source
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. Both are potent anti-inflammatory polyphenols that modulate NF-κB and COX-2 through complementary mechanisms.
Mechanism. Curcumin inhibits IKK-β, blocking NF-κB nuclear translocation. Quercetin inhibits lipoxygenase and phospholipase A2. Both inhibit COX-2 through different binding mechanisms.
Recommendation. Take together for enhanced anti-inflammatory and antioxidant effects.
Sources (1)
- Pescosolido N et al. Curcumin and quercetin synergistically inhibit inflammatory signaling. J Cell Mol Med. 2013
Stack Score
How this pair moves the number.
Effect on the composite score
If both Curcumin Phytosome and Quercetin are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
Check your full routine
One pair was the worked example. NutriStack runs every pair in your stack at once.
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