NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Prescription·Evidence index

Curcumin Phytosome and Diclofenac: what the published research says

PubMed indexes 8 records that name Curcumin Phytosome and Diclofenac together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

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An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Curcumin Phytosome and Diclofenac. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

8 studies naming Curcumin Phytosome and Diclofenac.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Safety and efficacy of curcumin versus diclofenac in knee osteoarthritis: a randomized open-label parallel-arm study.

Trials · 2019 · PMID 30975196

Comparative StudyRandomized Controlled Trial

“Curcumin has similar efficacy to diclofenac but demonstrated better tolerance among patients with knee OA. Curcumin can be an alternative treatment option in the patients with knee OA who are intolerant to the side effects of non-steroidal anti-inflammatory drugs.”

Shep et al. · Authors' conclusion

Names both Curcumin Phytosome and Diclofenac in its title.

The comparison of preemptive analgesic effects of curcumin and diclofenac.

Bratislavske lekarske listy · 2014 · PMID 25520223

Comparative StudyAnimal study

“These results suggest that curcumin had preemptive analgesic effects on acute thermal, and inflammatory induced pain in rats as diclofenac (Fig. 2, Ref. 35).”

Nurullahoglu et al. · Authors' conclusion

Names both Curcumin Phytosome and Diclofenac in its title.

QbD Approach for the Development of Tea Tree Oil-Enhanced Microemulgel Loaded with Curcumin and Diclofenac for Rheumatoid Arthritis Treatment.

Gels (Basel, Switzerland) · 2024 · PMID 39451289

“In vitro permeability demonstrated significant potential for the effective delivery of diclofenac and curcumin to targeted sites, compared to conventional gel. Therefore, it was deduced that the Tea tree oil integrated diclofenac and curcumin microemulsion gel could enhance the effectiveness of diclofenac and serve as a promising vehicle for rheumatoid arthritis treatment.”

Pathak et al. · From the abstract

Names both Curcumin Phytosome and Diclofenac in its title.

Curcumin and Diclofenac Therapeutic Efficacy Enhancement Applying Transdermal Hydrogel Polymer Films, Based on Carrageenan, Alginate and Poloxamer.

Polymers · 2022 · PMID 36236036

“The results obtained using theoretical models suggested that curcumin establishes stronger, primarily dispersion interactions with carrier, in comparison with diclofenac. Curcumin and diclofenac-loaded films showed great antibacterial activity against Gram-positive bacteria strains (Bacillus subtilis and Staphylococcus aureus, inhibition zone 16.67 and 13.67 mm, respectively), and in vitro and in vivo studies indicated that curcumin- and diclofenac-incorporated polymer films…”

Postolović et al. · From the abstract

Names both Curcumin Phytosome and Diclofenac in its title.

Curcumin Nanoparticles Enhance Antioxidant Efficacy of Diclofenac Sodium in Experimental Acute Inflammation.

Biomedicines · 2021 · PMID 35052741

“The nC enhanced the antioxidative efficacy of D, as this combination reduced the pro-oxidant markers up to 1.3 times. Curcumin nanoparticles could represent a therapeutic option in association with classical nonsteroidal anti-inflammatory medication in acute inflammation, as they might offer a reduction of drug dose and possible limitation of their associated side effects.”

Boarescu et al. · From the abstract

Names both Curcumin Phytosome and Diclofenac in its title.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Curcumin Phytosome, Diclofenac, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.