NutriStack
Apixaban and Quercetin, a caution.
Quercetin inhibits CYP3A4 and P-glycoprotein in vitro. Apixaban is metabolised by CYP3A4 and is a P-gp substrate, so high-dose quercetin supplements could raise apixaban plasma concentrations and bleeding risk. The interaction is plausible but human data are limited.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Quercetin inhibits CYP3A4 and P-glycoprotein in vitro. Apixaban is metabolised by CYP3A4 and is a P-gp substrate, so high-dose quercetin supplements could raise apixaban plasma concentrations and bleeding risk. The interaction is plausible but human data are limited.
Mechanism. Quercetin and its metabolites inhibit CYP3A4 and P-glycoprotein, two pathways responsible for apixaban metabolism and intestinal/biliary efflux. Inhibition would raise apixaban exposure (AUC) and bleeding risk.
Recommendation. Avoid high-dose quercetin supplements (500 mg or more daily) on apixaban. Dietary intake from fruits and vegetables is not a concern. If you take a supplement, watch for unusual bruising or bleeding and tell your prescriber.
Sources (2)
- Foti RS, Wahlstrom JL, Wienkers LC. The in vitro drug interaction potential of dietary supplements. J Pharm Sci. 2007;96(9):2358-79. (Quercetin CYP3A4/P-gp inhibition.) PMID 17593555
- Mendell J, Zahir H, Matsushima N, et al. Drug-drug interaction studies of cardiovascular drugs involving P-glycoprotein, an efflux transporter, on the pharmacokinetics of edoxaban, an oral factor Xa inhibitor. Am J Cardiovasc Drugs. 2013;13(5):331-42. (DOAC P-gp mediated DDIs.) PMID 23784266
Stack Score
How this pair moves the number.
Effect on the composite score
If both Apixaban and Quercetin are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
Check your full routine
One pair was the worked example. NutriStack runs every pair in your stack at once.
Drop in your supplements and prescriptions and the public database surfaces every interaction, synergy, timing rule, and contraindication, every one linked to its primary source.