What kind of interaction is it?

Synergy: a documented combination effect that is stronger or more useful than either substance taken alone.

Is this interaction backed by published research?

Yes. NutriStack lists 1 citation row for the Luteolin + Quercetin pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Supplement × Supplement·a synergy·Emerging evidence

Luteolin + Quercetin

Q: Can I take Luteolin and Quercetin together?

Yes. The combination of Luteolin and Quercetin produces a measurable benefit. Luteolin and quercetin are both flavonoids with overlapping mast-cell-stabilizing, antihistaminic, and NF-kappaB-inhibiting anti-inflammatory activity, and they are frequently co-formulated for allergy and neuroinflammatory support.

Q: How does this affect a NutriStack Stack Score?

+2 to your Stack Score per scored synergy row.

Synergy Emerging evidence

Luteolin and quercetin are both flavonoids with overlapping mast-cell-stabilizing, antihistaminic, and NF-kappaB-inhibiting anti-inflammatory activity, and they are frequently co-formulated for allergy and neuroinflammatory support.

Supplement × Supplement

Open the interaction checker → Read the methodology

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Substances

Luteolin and Quercetin

Pair type

Synergy

Evidence

Emerging

Source citations

Scope

Supplement × Supplement

Last verified

June 4, 2026

SynergyEmerging evidence

What is happening. Luteolin and quercetin are both flavonoids with overlapping mast-cell-stabilizing, antihistaminic, and NF-kappaB-inhibiting anti-inflammatory activity, and they are frequently co-formulated for allergy and neuroinflammatory support.

Mechanism. Both flavones/flavonols stabilize mast cells and inhibit pro-inflammatory transcription factors; effects are largely complementary rather than redundant.

Recommendation. Combining is reasonable for additive flavonoid effects. Because both are flavonoids that inhibit CYP and UGT enzymes, be cautious when also taking narrow-therapeutic-index medications and discuss with a clinician.

Stack Score

How it moves the number.

Effect on the composite score

If both Luteolin and Quercetin are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1Theoharides TC, et al. Luteolin as a therapeutic option for multiple sclerosis and neuroinflammation. Journal of Neuroinflammation. 2018.Needs sourceNo link

Check your full routine

One pair was the worked example.

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Open the interaction checker → Browse the research index