NutriStack
Celecoxib and Turmeric/Curcumin, a caution.
Both celecoxib and curcumin inhibit COX-2. Combined use may provide additive anti-inflammatory effects but also increases the risk of GI and cardiovascular side effects.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Celecoxib and Turmeric/Curcumin
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 1 source
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Both celecoxib and curcumin inhibit COX-2. Combined use may provide additive anti-inflammatory effects but also increases the risk of GI and cardiovascular side effects.
Mechanism. Celecoxib selectively inhibits COX-2. Curcumin also inhibits COX-2 and NF-kB. Dual COX-2 inhibition may increase the anti-inflammatory effect but also the cardiovascular and renal risks associated with excessive prostaglandin suppression.
Recommendation. Use low-dose curcumin if combining. The additive COX-2 inhibition may increase cardiovascular and GI risk.
Stack Score
How this pair moves the number.
Effect on the composite score
If both Celecoxib and Turmeric/Curcumin are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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