NutriStack
Lisinopril and Lithium, a caution.
ACE inhibitors reduce renal lithium clearance, potentially increasing lithium levels by 25-40% and causing lithium toxicity. Symptoms include tremor, nausea, confusion, and potentially seizures.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Lisinopril and Lithium
- Pair type
- Caution
- Evidence (highest tier)
- Strong
- Source citations
- 1 source
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Strong evidence
Caution
What is happening. ACE inhibitors reduce renal lithium clearance, potentially increasing lithium levels by 25-40% and causing lithium toxicity. Symptoms include tremor, nausea, confusion, and potentially seizures.
Mechanism. ACE inhibitors reduce angiotensin II-mediated aldosterone secretion, promoting sodium and water retention in the proximal tubule. Since lithium is reabsorbed with sodium, reduced sodium excretion leads to increased lithium reabsorption.
Recommendation. Monitor lithium levels closely when starting, stopping, or adjusting ACE inhibitor dose. Reduce lithium dose as needed. Watch for toxicity symptoms.
Stack Score
How this pair moves the number.
Effect on the composite score
If both Lisinopril and Lithium are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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