NutriStack
L-Arginine and Lisinopril, a synergy.
L-Arginine is the substrate for endothelial nitric oxide synthase, and oral supplementation produces modest blood pressure reductions (about 5 mm Hg systolic in a meta-analysis of double-blind trials). ACE inhibitors like lisinopril also raise nitric oxide bioavailability through bradykinin. The effects are additive and generally beneficial.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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What the row says.
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At a glance
- Substances
- L-Arginine and Lisinopril
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. L-Arginine is the substrate for endothelial nitric oxide synthase, and oral supplementation produces modest blood pressure reductions (about 5 mm Hg systolic in a meta-analysis of double-blind trials). ACE inhibitors like lisinopril also raise nitric oxide bioavailability through bradykinin. The effects are additive and generally beneficial.
Mechanism. L-Arginine increases nitric oxide synthesis by providing substrate to eNOS, promoting vasodilation. ACE inhibition independently raises bradykinin and nitric oxide. Combined endothelial effects produce additive blood pressure reduction.
Recommendation. L-Arginine 3-6 g/day is a reasonable add-on; monitor home blood pressure after starting and tell your prescriber so your lisinopril dose can be reviewed. Avoid combination with sildenafil or tadalafil without medical guidance.
Sources (2)
- Dong JY, Qin LQ, Zhang Z, Zhao Y, Wang J, Arigoni F, Zhang W. Effect of oral L-arginine supplementation on blood pressure: a meta-analysis of randomized, double-blind, placebo-controlled trials. Am Heart J. 2011;162(6):959-65. PMID 22137067
- Komers R, Komersova K, Kazdova L, Ruzickova J, Pelikanova T. Effect of ACE inhibition and angiotensin AT1 receptor blockade on renal and blood pressure response to L-arginine in humans. J Hypertens. 2000;18(1):51-9. PMID 10678543
Stack Score
How this pair moves the number.
Effect on the composite score
If both L-Arginine and Lisinopril are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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