Study of supplemental oral l-arginine in hypertensives treated with enalapril + hydrochlorothiazide.
Clinical TrialLetterRandomized Controlled Trial
Names both Hydrochlorothiazide and L-Arginine in its title.
Supplement × Prescription·Evidence index
PubMed indexes 5 records that name Hydrochlorothiazide and L-Arginine together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.
Every statement below is attributed to a named, dated, linked source.
This page lists published research relevant to Hydrochlorothiazide and L-Arginine. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.
Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.
Names both Hydrochlorothiazide and L-Arginine in its title.
Names both Hydrochlorothiazide and L-Arginine in its title.
Names Hydrochlorothiazide and L-Arginine together in an interaction, co-administration, or pharmacokinetic context.
“Although experimental data can be hardly extrapolated to clinical practice, it is suggested that perindopril arginine may positively influence the anticonvulsant action of LEV in epileptic patients. The use of losartan potassium, candesartan cilexetil, captopril, hydrochlorothiazide or ethacrynic acid in patients treated with LEV seems neutral regarding its anticonvulsant activity.”
Names Hydrochlorothiazide and L-Arginine together in an interaction, co-administration, or pharmacokinetic context.
“Reduced BP with nebivolol in hypertensive African Americans and echocardiographic evidence of diastolic dysfunction correlates with improved endothelial function. Furthermore, improvement in endothelial function and increased nitric oxide bioavailability suggests a potential mechanism of efficacy of nebivolol in these patients.”
Names Hydrochlorothiazide and L-Arginine together in an interaction, co-administration, or pharmacokinetic context.
Search-based evidence indexes have real limits, and it is worth being explicit about them:
NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Hydrochlorothiazide, L-Arginine, and several hundred other substances.
The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.
NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.