NutriStack
L-Arginine and L-Citrulline, a synergy.
Citrulline is converted to arginine in the kidney, raising plasma arginine higher and longer than oral arginine alone. Combined use provides additive NO support.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- L-Arginine and L-Citrulline
- Pair type
- Synergy
- Evidence (highest tier)
- Strong
- Source citations
- 1 source
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Strong evidence
Synergy
What is happening. Citrulline is converted to arginine in the kidney, raising plasma arginine higher and longer than oral arginine alone. Combined use provides additive NO support.
Mechanism. Citrulline bypasses first-pass arginase metabolism in the gut, raising sustained plasma arginine and supporting nitric oxide synthesis more effectively.
Recommendation. Use citrulline as the primary NO precursor; if combining with arginine, take citrulline 1 to 2 hours before arginine or together pre-workout.
Sources (1)
- Schwedhelm E et al. Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. Br J Clin Pharmacol. 2008
Stack Score
How this pair moves the number.
Effect on the composite score
If both L-Arginine and L-Citrulline are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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