Supplement × Supplement·a conflict·Strong evidence

Citrulline Malate + L-Citrulline

Conflict Strong evidence

Citrulline malate already supplies citrulline, so adding L-citrulline can create duplicate high dosing and GI effects.

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Pair type
Conflict
Evidence
Strong
Source citations
1
Scope
Supplement × Supplement
Last verified
June 4, 2026
ConflictStrong evidence

What is happening. Citrulline malate already supplies citrulline, so adding L-citrulline can create duplicate high dosing and GI effects.

Mechanism. Duplicate citrulline raises arginine and nitric oxide pathways.

Recommendation. Count total citrulline from all products and reduce doses if stacking.

Stack Score

How it moves the number.

Effect on the composite score

If both Citrulline Malate and L-Citrulline are in the same stack, this pair applies −10 to your Stack Score (per scored conflict row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1
  • 1Trexler ET et al. Citrulline meta-analysis. Sports Med. 2019.Needs sourceNo link

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