Effects of Citrulline Malate Supplementation on Exercise Performance: A Systematic Review and Three-Level Meta-Analysis.
Systematic ReviewMeta-AnalysisReviewHuman subjects
Names both Citrulline Malate and L-Citrulline in its title.
Supplement × Supplement·Evidence index
PubMed indexes 8 records that name Citrulline Malate and L-Citrulline together, either in the title or in an interaction, co-administration, or pharmacokinetic context. The key findings come first, in the authors’ own words, followed by every study with its design and PubMed link.
A summary of published research, not medical advice. A pharmacist can check any combination against your full list of medicines and supplements.
Reviews and human studies first. Each quote is the authors’ own conclusion about their study, not a NutriStack assessment, and a single study is not a consensus.
“The mean effects were similar for "limbs" (upper vs lower) [p = 0.763]. Accordingly, our findings suggest that citrulline malate supplementation does not improve muscle strength in healthy and resistance-trained individuals (PROSPERO registration number: CRD42020159338).”
“Six weeks of CM supplementation combined with multicomponent training was associated with improved sit-to-stand performance in older women, with additional favourable trends in walking endurance, SPPB score, and 25(OH)D. Given the pilot nature of the study, these findings should be considered preliminary and hypothesis-generating. Larger and longer trials are needed to confirm the reproducibility, clinical…”
Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.
Names both Citrulline Malate and L-Citrulline in its title.
“The mean effects were similar for "limbs" (upper vs lower) [p = 0.763]. Accordingly, our findings suggest that citrulline malate supplementation does not improve muscle strength in healthy and resistance-trained individuals (PROSPERO registration number: CRD42020159338).”
Names both Citrulline Malate and L-Citrulline in its title.
Names both Citrulline Malate and L-Citrulline in its title.
Names both Citrulline Malate and L-Citrulline in its title.
“Six weeks of CM supplementation combined with multicomponent training was associated with improved sit-to-stand performance in older women, with additional favourable trends in walking endurance, SPPB score, and 25(OH)D. Given the pilot nature of the study, these findings should be considered preliminary and hypothesis-generating. Larger and longer trials are needed to confirm the reproducibility, clinical significance, and potential mechanisms of these effects.”
Names both Citrulline Malate and L-Citrulline in its title.
Names both Citrulline Malate and L-Citrulline in its title.
Names both Citrulline Malate and L-Citrulline in its title.
Names both Citrulline Malate and L-Citrulline in its title.
Search-based evidence indexes have real limits, and it is worth being explicit about them:
NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Citrulline Malate, L-Citrulline, and several hundred other substances.
Log your routine, get reminders at the times you choose, and scan a label to add a product. The checker is a research and organisation tool, not a clinical decision aid.
NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.