Supplement × Supplement·a synergy·Moderate evidence
Creatine and citrulline target different performance mechanisms.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
What is happening. Creatine and citrulline target different performance mechanisms.
Mechanism. Phosphocreatine energy support plus nitric oxide-mediated blood flow.
Recommendation. Can combine in a pre-workout stack if GI tolerance is acceptable.
Effect on the composite score
If both Citrulline Malate and Creatine are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
Every claim on this page is cited. PMIDs link straight to PubMed.
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NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.
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