From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Scope
Supplement × Supplement
Last verified
June 4, 2026
SynergyEmerging evidence
What is happening. Creatine has stronger evidence and may complement any experimental anabolic signaling from ecdysterone.
Mechanism. Training-volume support plus possible protein-synthesis signaling.
Recommendation. Use creatine as the evidence-based foundation and treat ecdysterone as optional experimental add-on.
Stack Score
How it moves the number.
Effect on the composite score
If both Creatine and Ecdysterone are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
SourcesSources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1Isenmann E et al. Ecdysterone supplementation in humans. Arch Toxicol. 2019.Needs sourceNo link