What kind of interaction is it?

Caution: an interaction that may reduce efficacy or raise side-effect risk and warrants monitoring.

Is this interaction backed by published research?

Yes. NutriStack lists 1 citation row for the Creatine + Tenofovir Disoproxil pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Supplement × Prescription·a caution·Emerging evidence

Creatine + Tenofovir Disoproxil

Q: Can I take Creatine and Tenofovir Disoproxil together?

Possibly, but with caution. Creatine and Tenofovir Disoproxil have a documented caution-tier interaction. Creatine can raise measured serum creatinine and complicate renal assessment for Tenofovir Disoproxil, which depends on kidney function for dosing or toxicity monitoring.

Q: How does this affect a NutriStack Stack Score?

-5 to your Stack Score per scored caution row.

Caution Emerging evidence

Creatine can raise measured serum creatinine and complicate renal assessment for Tenofovir Disoproxil, which depends on kidney function for dosing or toxicity monitoring.

Supplement × Prescription

Open the interaction checker → Read the methodology

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Substances

Creatine and Tenofovir Disoproxil

Pair type

Caution

Evidence

Emerging

Source citations

Scope

Supplement × Prescription

Last verified

June 4, 2026

CautionEmerging evidence

What is happening. Creatine can raise measured serum creatinine and complicate renal assessment for Tenofovir Disoproxil, which depends on kidney function for dosing or toxicity monitoring.

Mechanism. Creatine conversion to creatinine can confound creatinine-based eGFR interpretation; dehydration or kidney disease increases concern.

Recommendation. Tell the prescriber about creatine use and avoid creatine loading during acute illness, kidney injury, or therapy requiring close renal dosing.

Stack Score

How it moves the number.

Effect on the composite score

If both Creatine and Tenofovir Disoproxil are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1DailyMed labeling and renal dosing guidance for the affected drug; creatine renal marker reviews.Needs sourceNo link

Check your full routine

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Open the interaction checker → Browse the research index