From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Scope
Supplement × Prescription
Last verified
June 4, 2026
SynergyModerate evidence
What is happening. Adequate calcium intake is relevant because tenofovir disoproxil can reduce bone mineral density.
Mechanism. Bone-risk mitigation rather than a drug-level interaction.
Recommendation. Use dietary calcium or supplements only to meet total intake goals; avoid excess in kidney stone or kidney disease risk.
Stack Score
How it moves the number.
Effect on the composite score
If both Calcium and Tenofovir Disoproxil are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
SourcesSources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1DailyMed. Tenofovir Disoproxil US prescribing information. 2026.Needs sourceNo link