Interaction databaseSupplement × SupplementReviewed May 2026

L-Citrulline and Taurine, a synergy.

Both amino acids support endothelial function and exercise performance, and are commonly combined for complementary vascular and ergogenic effects.

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

Sourcing standards·Evidence tiers

From the interaction database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.

At a glance

Substances
L-Citrulline and Taurine
Pair type
Synergy
Evidence (highest tier)
Emerging
Source citations
1 source
Stack Score effect
+2 to your Stack Score (per scored synergy row).
Scope
Supplement × Supplement
Last verified
May 30, 2026

Synergy · Emerging evidence

Synergy

What is happening. Both amino acids support endothelial function and exercise performance, and are commonly combined for complementary vascular and ergogenic effects.

Mechanism. L-citrulline raises arginine and nitric oxide driven vasodilation, while taurine supports endothelial function, intracellular calcium handling in muscle, and antioxidant defense, giving complementary vascular and ergogenic effects.

Recommendation. Reasonable to take together pre-exercise for blood flow and performance support; effects are complementary rather than competitive and no time separation is needed.

Sources (1)
  1. Schaffer SW et al. Physiological roles of taurine in heart and muscle. J Biomed Sci. 2010;17 Suppl 1(Suppl 1):S2. PMID 20804594

Stack Score

How this pair moves the number.

Effect on the composite score

If both L-Citrulline and Taurine are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

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