NutriStack
Diltiazem and Taurine, a caution.
Taurine produces small but consistent reductions in blood pressure (about 3-4 mmHg systolic in meta-analysis) and slows heart rate through autonomic modulation. Added to diltiazem's negative chronotropic and vasodilatory effects, the combination can produce additive bradycardia or hypotension, particularly in older patients or those on additional rate-slowing medications.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Pair type
- Caution
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Moderate evidence
Caution
What is happening. Taurine produces small but consistent reductions in blood pressure (about 3-4 mmHg systolic in meta-analysis) and slows heart rate through autonomic modulation. Added to diltiazem's negative chronotropic and vasodilatory effects, the combination can produce additive bradycardia or hypotension, particularly in older patients or those on additional rate-slowing medications.
Mechanism. Taurine modulates intracellular calcium handling, suppresses sympathetic outflow, and increases nitric oxide availability. These effects overlap with diltiazem's L-type calcium channel blockade and AV-nodal slowing.
Recommendation. If you take diltiazem, taurine doses up to 1.5-3 g/day are usually tolerable, but check blood pressure and pulse when you start. Hold or reduce taurine if your HR drops below 50 bpm or you develop new dizziness or fatigue.
Sources (2)
- Tzang CC, Lin WC, Lin LH, et al. Insights into the cardiovascular benefits of taurine: a systematic review and meta-analysis. Nutr J. 2024;23(1):93. PMID 39148075
- Mills TA, Kawji MM, Cataldo VD, et al. Profound sinus bradycardia due to diltiazem, verapamil, and/or beta-adrenergic blocking drugs. J La State Med Soc. 2004;156(6):327-31. PMID 15688675
Stack Score
How this pair moves the number.
Effect on the composite score
If both Diltiazem and Taurine are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
Check your full routine
One pair was the worked example. NutriStack runs every pair in your stack at once.
Drop in your supplements and prescriptions and the public database surfaces every interaction, synergy, timing rule, and contraindication, every one linked to its primary source.