NutriStack
L-Arginine and Pine Bark Extract, a synergy.
Pine bark extract (Pycnogenol) combined with L-arginine improved erectile function and endothelial nitric oxide signaling in controlled clinical trials more than expected from either alone.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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What the row says.
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At a glance
- Substances
- L-Arginine and Pine Bark Extract
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. Pine bark extract (Pycnogenol) combined with L-arginine improved erectile function and endothelial nitric oxide signaling in controlled clinical trials more than expected from either alone.
Mechanism. L-arginine is the substrate for nitric oxide synthase while pine bark procyanidins increase eNOS activity and protect nitric oxide from oxidative degradation, jointly enhancing endothelial NO availability.
Recommendation. A reasonable evidence-based pairing for vascular and erectile support. People on blood-pressure-lowering medication should monitor for additive hypotension.
Sources (2)
- Stanislavov R, Nikolova V. Treatment of erectile dysfunction with pycnogenol and L-arginine. Journal of Sex and Marital Therapy, 2003
- Stanislavov R et al. Sexual function in men using a combination of pycnogenol and L-arginine aspartate (Prelox). International Journal of Impotence Research, 2009
Stack Score
How this pair moves the number.
Effect on the composite score
If both L-Arginine and Pine Bark Extract are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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