NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Prescription·Evidence index

Alcohol and Hydrochlorothiazide: what the published research says

PubMed indexes 6 records that name Alcohol and Hydrochlorothiazide together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Alcohol and Hydrochlorothiazide. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

6 studies naming Alcohol and Hydrochlorothiazide.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Captopril and hydrochlorothiazide (Capozide) combine to enhance the reduction in voluntary alcohol intake in rats.

Alcoholism, clinical and experimental research · 1993 · PMID 8279680

Animal study

“These effects were not due to drug-induced changes in the pharmacokinetics of alcohol. Taken together these results demonstrate an enhanced potency of Capozide in suppressing alcohol intake and invite their testing in a population of hypertensive alcoholics and alcohol abusers.”

Robertson et al. · From the abstract

Names both Alcohol and Hydrochlorothiazide in its title.

Furosemide and spironolactone doses and hyponatremia in patients with heart failure.

BMC pharmacology & toxicology · 2020 · PMID 32746925

Observational StudyHuman subjects

“High doses of furosemide and spironolactone, or concomitant use of these diuretics, seem to be an important cause of hyponatremia in HF patients, particularly in combination with advanced age, diabetes and alcohol consumption. Diuretic dose reduction may help avoid hyponatremia and improve clinical status and prognosis in such patients.”

Velat et al. · Authors' conclusion

Names Alcohol and Hydrochlorothiazide together in an interaction, co-administration, or pharmacokinetic context.

Efficacy and safety of the losartan-hydrochlorothiazide combination tablet in patients with hypertension uncontrolled by angiotensin II receptor antagonist therapy: the Aichi Research on Combination therapy for Hypertension (ARCH) Study.

Internal medicine (Tokyo, Japan) · 2012 · PMID 22687785

Clinical TrialMulticenter Study648 participants

“The losartan-HCTZ combination tablet was found to have an early hypotensive effect, good tolerability, and stable long-term benefits in patients with hypertension uncontrolled by ARB monotherapy or combination therapy with a CCB.”

Maeda et al. · Authors' conclusion

Names Alcohol and Hydrochlorothiazide together in an interaction, co-administration, or pharmacokinetic context.

Probable interaction between warfarin and bee pollen.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists · 2010 · PMID 21098375

Case ReportsHuman subjects

“Consumption of bee pollen led to increased INR values in a patient taking warfarin.”

Hurren et al. · Authors' conclusion

Names Alcohol and Hydrochlorothiazide together in an interaction, co-administration, or pharmacokinetic context.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Alcohol, Hydrochlorothiazide, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.