NutriStack
Furosemide and Lithium, a caution.
Loop diuretics can increase lithium levels through volume depletion, though the effect is generally less predictable than with thiazide diuretics. Dehydration from aggressive diuresis is particularly dangerous.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Furosemide and Lithium
- Pair type
- Caution
- Evidence (highest tier)
- Moderate
- Source citations
- 1 source
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Moderate evidence
Caution
What is happening. Loop diuretics can increase lithium levels through volume depletion, though the effect is generally less predictable than with thiazide diuretics. Dehydration from aggressive diuresis is particularly dangerous.
Mechanism. Furosemide causes natriuresis and volume depletion. Compensatory proximal tubular sodium reabsorption increases lithium reabsorption, raising serum levels. Dehydration compounds this effect.
Recommendation. Monitor lithium levels closely. Ensure adequate hydration. Check lithium levels within 5-7 days of diuretic initiation or dose change.
Sources (1)
Stack Score
How this pair moves the number.
Effect on the composite score
If both Furosemide and Lithium are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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