NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Prescription·Evidence index

Ciprofloxacin and Iron: what the published research says

PubMed indexes 7 records that name Ciprofloxacin and Iron together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Ciprofloxacin and Iron. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

7 studies naming Ciprofloxacin and Iron.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Cu(2)S-modified iron sludge with high activity and stability for ciprofloxacin removal in a Fenton-like system.

Journal of environmental sciences (China) · 2026 · PMID 42498361

“Besides, Short-chain intermediates were generated with lower molecular weight and reduced toxicity during the catalytic process. The research provides a scientific approach for developing iron sludge-based catalysts for wastewater treatment.”

Liang et al. · From the abstract

Names both Ciprofloxacin and Iron in its title.

Biopharmaceutical characterization of ciprofloxacin HCl-ferrous sulfate interaction.

Journal of pharmaceutical sciences · 2011 · PMID 21789771

“These results strongly indicate that ciprofloxacin-iron interaction in vivo is caused by the formation of a low soluble complex. This interaction was also simulated by in vitro dissolution, in which a mini scale apparatus provided more biorelevant results than the standard dissolution apparatus, probably because the drug concentrations in the mini apparatus were higher and, thus, closer to the conditions encountered in vivo.”

Parojčić et al. · From the abstract

Names both Ciprofloxacin and Iron in its title.

Iron-ovotransferrin preparation does not interfere with ciprofloxacin absorption.

Clinical pharmacology and therapeutics · 1996 · PMID 8612386

Human subjects

“Iron was also well absorbed from the formulation in the presence of a fatty meal. The very common drug interactions with oral iron preparations can be effectively prevented by the use of the iron-ovotransferrin complex interacting to a minimal extent with a sensitive drug with a reduced margin of efficacy, such as ciprofloxacin.”

Pazzucconi et al. · From the abstract

Names both Ciprofloxacin and Iron in its title.

Drug-drug interactions with fluoroquinolones.

Pharmacotherapy · 1993 · PMID 8474934

Comparative StudyReviewHuman subjects

Names Ciprofloxacin and Iron together in an interaction, co-administration, or pharmacokinetic context.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Ciprofloxacin, Iron, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.