NutriStack
Artemisinin and Iron, a caution.
Iron supplementation may modulate artemisinin activity, because artemisinin relies on iron to generate its cytotoxic free radicals and iron status can alter its pharmacodynamics.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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At a glance
- Substances
- Artemisinin and Iron
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 1 source
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Iron supplementation may modulate artemisinin activity, because artemisinin relies on iron to generate its cytotoxic free radicals and iron status can alter its pharmacodynamics.
Mechanism. Artemisinin contains an endoperoxide bridge that is cleaved by ferrous iron and heme to form reactive oxygen and carbon-centered radicals, so iron availability directly influences its radical-generating activity.
Recommendation. Use caution when combining iron with artemisinin and discuss with a clinician, especially during therapeutic antimalarial use.
Stack Score
How this pair moves the number.
Effect on the composite score
If both Artemisinin and Iron are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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