NutriStack
Artemisinin and NAC, a caution.
NAC is a potent antioxidant that can quench the reactive oxygen species artemisinin depends on, potentially reducing artemisinin's pro-oxidant effect.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Artemisinin and NAC
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 1 source
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. NAC is a potent antioxidant that can quench the reactive oxygen species artemisinin depends on, potentially reducing artemisinin's pro-oxidant effect.
Mechanism. Artemisinin works by generating free radicals after iron-mediated endoperoxide cleavage, while NAC replenishes glutathione and scavenges reactive oxygen species, which can antagonize the radical-mediated effect.
Recommendation. Avoid taking high-dose NAC alongside artemisinin if the goal is artemisinin's oxidative activity, separating their use or discussing timing with a clinician.
Stack Score
How this pair moves the number.
Effect on the composite score
If both Artemisinin and NAC are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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