NutriStack
Inositol and NAC, a synergy.
In polycystic ovary syndrome, myo-inositol and N-acetylcysteine target complementary problems: inositol supports insulin signaling while NAC provides antioxidant support and can improve ovulatory response.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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What the row says.
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At a glance
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. In polycystic ovary syndrome, myo-inositol and N-acetylcysteine target complementary problems: inositol supports insulin signaling while NAC provides antioxidant support and can improve ovulatory response.
Mechanism. Myo-inositol acts as a second messenger that improves insulin sensitivity and supports FSH signaling, while NAC replenishes glutathione and reduces ovarian oxidative stress, giving additive effects on ovulation and metabolic markers.
Recommendation. Reasonable to combine in a PCOS or insulin-resistance context. Typical research dosing is myo-inositol around 2g to 4g daily with NAC 600mg to 1800mg daily, ideally guided by a clinician.
Sources (2)
- Thakker D et al. N-acetylcysteine for polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled clinical trials. Obstetrics and Gynecology International. 2015
- Unfer V et al. Effects of myo-inositol in women with PCOS: a systematic review of randomized controlled trials. Gynecological Endocrinology. 2012
Stack Score
How this pair moves the number.
Effect on the composite score
If both Inositol and NAC are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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