NutriStack
L-Glutathione and NAC, a synergy.
NAC supplies cysteine, the rate-limiting precursor for endogenous glutathione synthesis, so co-supplementation can raise and sustain intracellular glutathione more effectively than oral glutathione alone.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- L-Glutathione and NAC
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. NAC supplies cysteine, the rate-limiting precursor for endogenous glutathione synthesis, so co-supplementation can raise and sustain intracellular glutathione more effectively than oral glutathione alone.
Mechanism. NAC is deacetylated to L-cysteine, the limiting substrate for the gamma-glutamylcysteine synthetase step in glutathione synthesis, replenishing the cysteine pool that oral glutathione poorly restores after gut breakdown.
Recommendation. Take together to support glutathione status; NAC at typical 600 to 1200 mg doses pairs well with oral or liposomal glutathione.
Sources (2)
- Atkuri KR et al, N-acetylcysteine: a safe antidote for cysteine/glutathione deficiency, Current Opinion in Pharmacology, 2007
- Sekhar RV et al, Glutathione synthesis is diminished in patients and restored by dietary supplementation, American Journal of Clinical Nutrition, 2011
Stack Score
How this pair moves the number.
Effect on the composite score
If both L-Glutathione and NAC are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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