NutriStack
Glycine and NAC, a synergy.
Glycine and NAC (GlyNAC) together provide two of the three amino acids needed for glutathione synthesis.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. Glycine and NAC (GlyNAC) together provide two of the three amino acids needed for glutathione synthesis.
Mechanism. Glutathione = glutamate + cysteine + glycine. NAC provides cysteine (rate-limiting), glycine is the second limiting substrate. Together they maximize GSH synthesis.
Recommendation. GlyNAC combination is a powerful glutathione-boosting strategy, particularly effective in aging adults.
Sources (2)
- Sekhar RV et al. GlyNAC supplementation improves glutathione deficiency and oxidative stress in aging. Clin Transl Med. 2021
- Kumar P, Liu C, Suliburk J, Hsu JW, Muthupillai R, Jahoor F et al.. Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial.. Journals of Gerontology Series A. 2023. PMID 35975308
Stack Score
How this pair moves the number.
Effect on the composite score
If both Glycine and NAC are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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