NutriStack
GABA and Glycine, a synergy.
Combining GABA with glycine layers two distinct inhibitory neurotransmitter systems, which can deepen overall central nervous system calming and support sleep onset.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. Combining GABA with glycine layers two distinct inhibitory neurotransmitter systems, which can deepen overall central nervous system calming and support sleep onset.
Mechanism. GABA is the primary inhibitory neurotransmitter acting on GABA-A and GABA-B receptors, while glycine is the chief inhibitory neurotransmitter in the brainstem and spinal cord acting on strychnine-sensitive glycine receptors and promoting a small drop in core body temperature that aids sleep onset.
Recommendation. Reasonable to stack before bed (for example GABA 100 to 200mg with glycine 3g). Start low if also taking other sedatives and assess next-morning grogginess.
Sources (2)
Stack Score
How this pair moves the number.
Effect on the composite score
If both GABA and Glycine are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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One pair was the worked example. NutriStack runs every pair in your stack at once.
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