NutriStack
GABA and Valerian Root, a caution.
Additive sedation and CNS depression, which can cause excessive drowsiness, especially if combined with alcohol or other sedatives.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- GABA and Valerian Root
- Pair type
- Caution
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Caution · Moderate evidence
Caution
What is happening. Additive sedation and CNS depression, which can cause excessive drowsiness, especially if combined with alcohol or other sedatives.
Mechanism. Valerian compounds enhance GABAergic transmission by acting on GABA-A receptors and inhibiting GABA breakdown, which can compound the inhibitory, sedating effects associated with supplemental GABA.
Recommendation. Use the combination only at night, avoid driving or operating machinery afterward, and do not combine with alcohol or prescription sedatives without medical advice.
Stack Score
How this pair moves the number.
Effect on the composite score
If both GABA and Valerian Root are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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