NutriStack
GABA and Passionflower, a caution.
Both target GABAergic tone, so combining supplemental GABA with passionflower can produce additive calming and sedative effects.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- GABA and Passionflower
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Both target GABAergic tone, so combining supplemental GABA with passionflower can produce additive calming and sedative effects.
Mechanism. Passionflower flavonoids potentiate GABA-A receptor activity, and supplemental GABA may contribute peripheral and possibly limited central GABAergic effects, yielding additive inhibitory tone.
Recommendation. Use modest doses, avoid combining before driving, and do not stack with prescription sedatives or alcohol.
Stack Score
How this pair moves the number.
Effect on the composite score
If both GABA and Passionflower are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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