NutriStack
Curcumin Phytosome and NAC, a synergy.
Both support liver detoxification and reduce oxidative stress. Curcumin is a direct antioxidant; NAC supports glutathione production.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Curcumin Phytosome and NAC
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 1 source
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. Both support liver detoxification and reduce oxidative stress. Curcumin is a direct antioxidant; NAC supports glutathione production.
Mechanism. Curcumin activates Nrf2, upregulating phase II detoxification enzymes. NAC provides cysteine for glutathione synthesis. Together they enhance both direct antioxidant defense and enzyme-mediated detoxification.
Recommendation. Combine for liver support and comprehensive antioxidant protection.
Sources (1)
- Biswas SK et al. Curcumin induces glutathione biosynthesis and inhibits NF-kappaB activation. Antioxid Redox Signal. 2005
Stack Score
How this pair moves the number.
Effect on the composite score
If both Curcumin Phytosome and NAC are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
Check your full routine
One pair was the worked example. NutriStack runs every pair in your stack at once.
Drop in your supplements and prescriptions and the public database surfaces every interaction, synergy, timing rule, and contraindication, every one linked to its primary source.