Supplement × Supplement·timing-sensitive·Moderate evidence

Anthocyanins (Bilberry Extract) + Iron

Timing Sensitive Moderate evidence

Polyphenols including anthocyanins and other flavonoids can chelate non-heme iron in the gut and reduce its absorption when consumed together.

From the database

What the row says.

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Pair type
Timing Sensitive
Evidence
Moderate
Source citations
1
Scope
Supplement × Supplement
Last verified
June 4, 2026
Timing SensitiveModerate evidence

What is happening. Polyphenols including anthocyanins and other flavonoids can chelate non-heme iron in the gut and reduce its absorption when consumed together.

Mechanism. Anthocyanins and related polyphenols form insoluble complexes with ferric iron in the intestinal lumen, lowering the bioavailability of non-heme iron.

Recommendation. If iron repletion is a goal, separate the bilberry extract from the iron dose by about 2 hours. Taking iron with vitamin C and away from polyphenol-rich foods or supplements improves uptake.

Timing

Timing & separation.

Space the doses apart by at least this window to avoid the conflict.

Minimum separation
120
Stack Score

How it moves the number.

Effect on the composite score

If both Anthocyanins (Bilberry Extract) and Iron are in the same stack, this pair applies −5 to your Stack Score (per scored timing-sensitive row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1
  • 1Hurrell RF, Egli I. Iron bioavailability and dietary reference values. American Journal of Clinical Nutrition. 2010.Needs sourceNo link

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