From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Pair type
Timing Sensitive
Scope
Supplement × Supplement
Last verified
June 4, 2026
Timing SensitiveModerate evidence
What is happening. Polyphenols including anthocyanins and other flavonoids can chelate non-heme iron in the gut and reduce its absorption when consumed together.
Mechanism. Anthocyanins and related polyphenols form insoluble complexes with ferric iron in the intestinal lumen, lowering the bioavailability of non-heme iron.
Recommendation. If iron repletion is a goal, separate the bilberry extract from the iron dose by about 2 hours. Taking iron with vitamin C and away from polyphenol-rich foods or supplements improves uptake.
TimingTiming & separation.
Space the doses apart by at least this window to avoid the conflict.
Stack Score
How it moves the number.
Effect on the composite score
If both Anthocyanins (Bilberry Extract) and Iron are in the same stack, this pair applies −5 to your Stack Score (per scored timing-sensitive row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
SourcesSources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1Hurrell RF, Egli I. Iron bioavailability and dietary reference values. American Journal of Clinical Nutrition. 2010.Needs sourceNo link