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Supplement × Supplement·Evidence index

Carnosine and Zinc: what the research found

PubMed indexes 8 records that name Carnosine and Zinc together, either in the title or in an interaction, co-administration, or pharmacokinetic context. The key findings come first, in the authors’ own words, followed by every study with its design and PubMed link.

A summary of published research, not medical advice. A pharmacist can check any combination against your full list of medicines and supplements.

Key findings

What the studies concluded.

Reviews and human studies first. Each quote is the authors’ own conclusion about their study, not a NutriStack assessment, and a single study is not a consensus.

“Zinc-L-carnosine is a safe and effective alternative to thickened formula in treating persistent infant regurgitation, after the failure of non-pharmacological measures. Its lower cost and promising clinical effect support further investigation in larger pediatric cohorts.”

Piccirillo et al. · 2026 · Human study · details

“CONCLUSIONS These case reports suggest that zinc L-carnosine can improve both dyspeptic symptoms and histologic features of CAG, thereby potentially reducing progression to gastric cancer. Larger clinical studies are warranted to confirm these findings.”

De Bastiani et al. · 2025 · Human study · details

“The physical symptoms of zinc deficiency eventually resolved. Further investigation of cotreatment with zinc and L-carnosine for DID and related conditions, particularly the contribution of zinc deficiency to dissociation, is necessary.”

The research

8 studies naming Carnosine and Zinc.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Zinc-L-Carnosine (Polaprezinc) in managing infant regurgitation: a two-center randomized controlled trial.

Frontiers in pediatrics · 2026 · PMID 42093671

Clinical Trial

“Zinc-L-carnosine is a safe and effective alternative to thickened formula in treating persistent infant regurgitation, after the failure of non-pharmacological measures. Its lower cost and promising clinical effect support further investigation in larger pediatric cohorts.”

Piccirillo et al. · Authors' conclusion

Names both Carnosine and Zinc in its title.

Improvement in Chronic Atrophic Gastritis After Treatment with Zinc L-Carnosine.

The American journal of case reports · 2025 · PMID 41264559

Case ReportsHuman subjects

“CONCLUSIONS These case reports suggest that zinc L-carnosine can improve both dyspeptic symptoms and histologic features of CAG, thereby potentially reducing progression to gastric cancer. Larger clinical studies are warranted to confirm these findings.”

De Bastiani et al. · From the abstract

Names both Carnosine and Zinc in its title.

Dissociative Identity Disorder Cotreated With Zinc and L-carnosine: A Case Report.

Cureus · 2024 · PMID 39737293

Case Reports

“The physical symptoms of zinc deficiency eventually resolved. Further investigation of cotreatment with zinc and L-carnosine for DID and related conditions, particularly the contribution of zinc deficiency to dissociation, is necessary.”

Sakae et al. · From the abstract

Names both Carnosine and Zinc in its title.

The Role of Zinc in the Development of Vascular Dementia and Parkinson's Disease and the Potential of Carnosine as Their Therapeutic Agent.

Biomedicines · 2024 · PMID 38927502

Review

“Carnosine may be a therapeutic drug for VD and PD. Furthermore, we reviewed the molecular mechanisms that involve the role of carnosine as an endogenous protector and its protective effect against Zn2+-induced cytotoxicity and discussed the prospects for the future therapeutic applications of this dipeptide for neurodegenerative diseases and dementia.”

Mizuno et al. · From the abstract

Names both Carnosine and Zinc in its title.

Carnosine, Zinc and Copper: A Menage a Trois in Bone and Cartilage Protection.

International journal of molecular sciences · 2023 · PMID 38003398

ReviewHuman subjects

“We hypothesize that polaprezinc could exchange Zn for Cu, present in the culture media, due to its higher sequestering ability towards Cu. However, future studies should unveil the potential contribution of Cu in the beneficial effects of polaprezinc.”

Ciaffaglione et al. · From the abstract

Names both Carnosine and Zinc in its title.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

How to read this page

A literature summary, not guidance.

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Carnosine, Zinc, and several hundred other substances.

Log your routine, get reminders at the times you choose, and scan a label to add a product. The checker is a research and organisation tool, not a clinical decision aid.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.