NutriStack
Vitamin A and Zinc, a synergy.
Zinc is required for retinol-binding protein synthesis and vitamin A transport from the liver. Zinc deficiency impairs vitamin A mobilization.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Pair type
- Synergy
- Evidence (highest tier)
- Strong
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Strong evidence
Synergy
What is happening. Zinc is required for retinol-binding protein synthesis and vitamin A transport from the liver. Zinc deficiency impairs vitamin A mobilization.
Mechanism. Zinc is essential for hepatic synthesis of retinol-binding protein (RBP) which transports retinol from liver stores to target tissues. Zinc also supports alcohol dehydrogenase for retinol→retinal conversion.
Recommendation. Ensure adequate zinc when supplementing vitamin A. Zinc deficiency can cause functional vitamin A deficiency even with adequate liver stores.
Sources (2)
- Christian P, West KP Jr. Interactions between zinc and vitamin A. Am J Clin Nutr. 1998
- Oh C, Keats EC, Bhutta ZA. Vitamin and Mineral Supplementation During Pregnancy on Maternal, Birth, Child Health and Development Outcomes in Low- and Middle-Income Countries: A Systematic Review and Meta-Analysis.. Nutrients. 2020. PMID 32075071
Stack Score
How this pair moves the number.
Effect on the composite score
If both Vitamin A and Zinc are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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