What kind of interaction is it?

Caution: an interaction that may reduce efficacy or raise side-effect risk and warrants monitoring.

Is this interaction backed by published research?

Yes. NutriStack lists 2 citation rows for the Captopril + Garlic Extract pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Supplement × Prescription·a caution·Moderate evidence

Captopril + Garlic Extract

Q: Can I take Captopril and Garlic Extract together?

Possibly, but with caution. Captopril and Garlic Extract have a documented caution-tier interaction. Garlic extract has modest blood-pressure-lowering properties and may add to the antihypertensive effect of captopril. While this can be beneficial, the additive effect could occasionally cause blood pressure to fall lower than intended, particularly when starting or up-titrating either agent.

Q: How does this affect a NutriStack Stack Score?

-5 to your Stack Score per scored caution row.

Caution Moderate evidence

Garlic extract has modest blood-pressure-lowering properties and may add to the antihypertensive effect of captopril. While this can be beneficial, the additive effect could occasionally cause blood pressure to fall lower than intended, particularly when starting or up-titrating either agent.

Supplement × Prescription

Open the interaction checker → Read the methodology

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Substances

Captopril and Garlic Extract

Pair type

Caution

Evidence

Moderate

Source citations

Scope

Supplement × Prescription

Last verified

June 4, 2026

CautionModerate evidence

What is happening. Garlic extract has modest blood-pressure-lowering properties and may add to the antihypertensive effect of captopril. While this can be beneficial, the additive effect could occasionally cause blood pressure to fall lower than intended, particularly when starting or up-titrating either agent.

Mechanism. Garlic constituents promote nitric oxide-mediated vasodilation and have mild ACE-inhibiting and diuretic-like effects, which can add pharmacodynamically to captopril's blood-pressure lowering.

Recommendation. The combination is generally acceptable and may be additive in a helpful way, but monitor blood pressure when adding garlic extract to captopril, especially at higher garlic doses. Report symptoms of low blood pressure such as dizziness, lightheadedness, or fainting.

Stack Score

How it moves the number.

Effect on the composite score

If both Captopril and Garlic Extract are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1Ried K, et al. Effect of garlic on blood pressure: a systematic review and meta-analysis. BMC Cardiovascular Disorders. 2008.Needs sourceNo link
2Ried K. Garlic lowers blood pressure in hypertensive individuals: a meta-analysis. Journal of Nutrition. 2016.Needs sourceNo link

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