NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Prescription·Evidence index

Captopril and Potassium: what the published research says

PubMed indexes 4 records that name Captopril and Potassium together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Captopril and Potassium. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

4 studies naming Captopril and Potassium.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Combined therapy with captopril and potassium supplementation. A potential for hyperkalemia.

Archives of internal medicine · 1984 · PMID 6391404

Human subjects

“The combination of captopril and potassium supplements or potassium-sparing diuretics represents a potentially important drug interaction. Patients should be closely monitored for possible hyperkalemia when using these drug combinations.”

Burnakis et al. · From the abstract

Names both Captopril and Potassium in its title.

Prevalence of drug interactions in hospitalised elderly patients: a systematic review.

European journal of hospital pharmacy : science and practice · 2021 · PMID 33355278

Systematic ReviewHuman subjects

“The prevalence of DDIs ranged widely, and the variation may reflect differences in the conditions of the elderly patients and level of attention (or complexity of care), as well as methodological differences, especially the methods and/or software used to identify DDIs.”

de Oliveira et al. · Authors' conclusion

Names Captopril and Potassium together in an interaction, co-administration, or pharmacokinetic context.

Interactions between levetiracetam and cardiovascular drugs against electroconvulsions in mice.

Pharmacological reports : PR · 2014 · PMID 25443741

Comparative StudyAnimal study

“Although experimental data can be hardly extrapolated to clinical practice, it is suggested that perindopril arginine may positively influence the anticonvulsant action of LEV in epileptic patients. The use of losartan potassium, candesartan cilexetil, captopril, hydrochlorothiazide or ethacrynic acid in patients treated with LEV seems neutral regarding its anticonvulsant activity.”

Lukawski et al. · Authors' conclusion

Names Captopril and Potassium together in an interaction, co-administration, or pharmacokinetic context.

ACE inhibitors in heart failure: what more do we need to know?

American journal of cardiovascular drugs : drugs, devices, and other interventions · 2005 · PMID 16259523

Comparative StudyReviewHuman subjects

Names Captopril and Potassium together in an interaction, co-administration, or pharmacokinetic context.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Captopril, Potassium, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.