NutriStack
Black Cohosh and Vitamin D3, a synergy.
Pairing black cohosh for menopausal vasomotor symptoms with vitamin D3 addresses a complementary need, since postmenopausal women face elevated bone loss risk that adequate vitamin D helps mitigate.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Black Cohosh and Vitamin D3
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. Pairing black cohosh for menopausal vasomotor symptoms with vitamin D3 addresses a complementary need, since postmenopausal women face elevated bone loss risk that adequate vitamin D helps mitigate.
Mechanism. Black cohosh acts on serotonergic and other central pathways to reduce hot flashes but does not protect bone, while vitamin D3 supports calcium absorption and bone mineralization; the two cover distinct aspects of menopausal health.
Recommendation. Reasonable to combine for menopausal women; ensure vitamin D intake supports bone health alongside symptom relief from black cohosh. No timing precautions needed.
Sources (2)
- North American Menopause Society, Nonhormonal management of menopause-associated vasomotor symptoms position statement, 2015
- Holick MF, Vitamin D deficiency, New England Journal of Medicine, 2007
Stack Score
How this pair moves the number.
Effect on the composite score
If both Black Cohosh and Vitamin D3 are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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