NutriStack
Canagliflozin and Chromium, a caution.
Canagliflozin lowers blood glucose through SGLT2 inhibition and chromium improves insulin sensitivity. The combination is usually well tolerated when canagliflozin is the only diabetes drug, but additive glucose-lowering becomes clinically meaningful if insulin or a sulfonylurea is also on board.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Canagliflozin and Chromium
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Canagliflozin lowers blood glucose through SGLT2 inhibition and chromium improves insulin sensitivity. The combination is usually well tolerated when canagliflozin is the only diabetes drug, but additive glucose-lowering becomes clinically meaningful if insulin or a sulfonylurea is also on board.
Mechanism. Canagliflozin inhibits SGLT2 (and weakly SGLT1) in the proximal renal tubule, increasing urinary glucose excretion. Chromium increases insulin receptor tyrosine kinase activity and peripheral glucose uptake, producing an additive effect on glycemia.
Recommendation. If canagliflozin is your only diabetes medication, chromium can be added with home glucose monitoring during the first 2-4 weeks. If you also take insulin or a sulfonylurea, ask your prescriber whether the other agent needs a dose reduction first.
Sources (2)
- Singer GM, Geohas J. The effect of chromium picolinate and biotin supplementation on glycemic control in poorly controlled patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized trial. Diabetes Technol Ther. 2006;8(6):636-43. PMID 17109595
- Havel PJ. A scientific review: the role of chromium in insulin resistance. Diabetes Educ. 2004;Suppl:2-14. PMID 15208835
Stack Score
How this pair moves the number.
Effect on the composite score
If both Canagliflozin and Chromium are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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