NutriStack
Chromium and Insulin Glargine, a caution.
Chromium enhances insulin sensitivity and may potentiate the glucose-lowering effect of insulin glargine, increasing hypoglycemia risk.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Chromium and Insulin Glargine
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 4 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Chromium enhances insulin sensitivity and may potentiate the glucose-lowering effect of insulin glargine, increasing hypoglycemia risk.
Mechanism. Chromium enhances insulin receptor signaling through chromodulin activation. This increases the glucose-lowering effect per unit of administered insulin.
Recommendation. Monitor blood glucose more closely when adding chromium. Low-dose chromium (200mcg/day) is generally safe. Higher doses may require insulin dose adjustment.
Sources (4)
- Cefalu WT, Hu FB. Role of chromium in human health and in diabetes. Diabetes Care. 2004;27(11):2741-2751. PMID 15505017
- Zhao F, Pan D, Wang N, Xia H, Zhang H, Wang S, Sun G. Effect of Chromium Supplementation on Blood Glucose and Lipid Levels in Patients with Type 2 Diabetes Mellitus: a Systematic Review and Meta-analysis. Biological Trace Element Research. 2022. PMID 33783683
- Vajdi M, Musazadeh V, Karimi A et al.. Effects of Chromium Supplementation on Lipid Profile: an Umbrella of Systematic Review and Meta-analysis. Biological Trace Element Research. 2023. PMID 36376714
- Tsang C, Taghizadeh M, Aghabagheri E, Asemi Z, Jafarnejad S. A meta-analysis of the effect of chromium supplementation on anthropometric indices of subjects with overweight or obesity. Clinical Obesity. 2019. PMID 31115179
Stack Score
How this pair moves the number.
Effect on the composite score
If both Chromium and Insulin Glargine are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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