NutriStack
Chromium and Semaglutide, a caution.
Chromium may enhance insulin sensitivity, adding to semaglutide's glucose-lowering effect. While the interaction is generally mild, it can contribute to lower-than-expected glucose levels.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Chromium and Semaglutide
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 4 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Chromium may enhance insulin sensitivity, adding to semaglutide's glucose-lowering effect. While the interaction is generally mild, it can contribute to lower-than-expected glucose levels.
Mechanism. Chromium potentiates insulin signaling by enhancing insulin receptor tyrosine kinase activity via chromodulin. Combined with semaglutide's GLP-1-mediated insulin secretion enhancement, additive glucose lowering can occur.
Recommendation. Monitor blood glucose when adding chromium to semaglutide therapy. Low-dose chromium (200mcg) is usually safe. Inform your prescriber about all supplements.
Sources (4)
- Balk EM et al. Effect of chromium supplementation on glucose metabolism and lipids: a systematic review of randomized controlled trials. Diabetes Care. 2007;30(8):2154-2163. PMID 17519436
- Zhao F, Pan D, Wang N, Xia H, Zhang H, Wang S, Sun G. Effect of Chromium Supplementation on Blood Glucose and Lipid Levels in Patients with Type 2 Diabetes Mellitus: a Systematic Review and Meta-analysis. Biological Trace Element Research. 2022. PMID 33783683
- Vajdi M, Musazadeh V, Karimi A et al.. Effects of Chromium Supplementation on Lipid Profile: an Umbrella of Systematic Review and Meta-analysis. Biological Trace Element Research. 2023. PMID 36376714
- Tsang C, Taghizadeh M, Aghabagheri E, Asemi Z, Jafarnejad S. A meta-analysis of the effect of chromium supplementation on anthropometric indices of subjects with overweight or obesity. Clinical Obesity. 2019. PMID 31115179
Stack Score
How this pair moves the number.
Effect on the composite score
If both Chromium and Semaglutide are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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