NutriStack
Cinnamon Extract and Insulin Glargine, a caution.
Cinnamon extract (particularly Cinnamomum cassia) has modest glucose-lowering properties, reducing fasting blood glucose and post-prandial glucose in clinical trials. The effect is generally small (10-20 mg/dL reduction) and unlikely to cause significant hypoglycemia when combined with insulin in most patients. However, high-dose concentrated cinnamon extracts combined with tight glycemic control on insulin may contribute to hypoglycemic episodes.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
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What the row says.
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At a glance
- Substances
- Cinnamon Extract and Insulin Glargine
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 1 source
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Cinnamon extract (particularly Cinnamomum cassia) has modest glucose-lowering properties, reducing fasting blood glucose and post-prandial glucose in clinical trials. The effect is generally small (10-20 mg/dL reduction) and unlikely to cause significant hypoglycemia when combined with insulin in most patients. However, high-dose concentrated cinnamon extracts combined with tight glycemic control on insulin may contribute to hypoglycemic episodes.
Mechanism. Cinnamon polyphenols, particularly cinnamaldehyde and procyanidins, enhance insulin sensitivity by activating insulin receptor kinase, increasing GLUT4 expression, and promoting glycogen synthesis. Methylhydroxychalcone polymer (MHCP) in cinnamon mimics insulin activity at the receptor level. These effects are additive with exogenous insulin but generally modest in magnitude.
Recommendation. Culinary cinnamon use is safe with insulin therapy. If using concentrated cinnamon extract supplements, inform your prescriber and monitor blood glucose. The glucose-lowering effect is modest but may be relevant in patients with tight glycemic targets. No specific timing separation is needed.
Stack Score
How this pair moves the number.
Effect on the composite score
If both Cinnamon Extract and Insulin Glargine are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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