From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Scope
Supplement × Supplement
Last verified
June 4, 2026
CautionInsufficient evidence
What is happening. Curcumin and KPV are both used for inflammation claims and may mask worsening symptoms if serious disease is untreated.
Mechanism. Overlapping anti-inflammatory symptom suppression.
Recommendation. Do not use supplement stacks to self-treat IBD, infection, or severe pain.
Stack Score
How it moves the number.
Effect on the composite score
If both Curcumin Phytosome and KPV are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
SourcesSources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1Catania A et al. alpha-MSH related peptides review. Ann N Y Acad Sci. 2006.Needs sourceNo link