NutriStack
Dexamethasone and Vitamin D2, a synergy.
Dexamethasone is a potent systemic glucocorticoid, and prolonged use can accelerate bone loss. Vitamin D2 can help maintain vitamin D status and calcium absorption as part of prevention for glucocorticoid-induced osteoporosis.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Dexamethasone and Vitamin D2
- Pair type
- Synergy
- Evidence (highest tier)
- Strong
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Strong evidence
Synergy
What is happening. Dexamethasone is a potent systemic glucocorticoid, and prolonged use can accelerate bone loss. Vitamin D2 can help maintain vitamin D status and calcium absorption as part of prevention for glucocorticoid-induced osteoporosis.
Mechanism. Dexamethasone suppresses osteoblast activity, favors bone resorption, and disrupts calcium balance. Vitamin D2 supports intestinal calcium absorption by increasing 25-OH vitamin D.
Recommendation. For repeated or long dexamethasone courses, maintain adequate vitamin D status and review fracture risk with your clinician. Vitamin D2 is supportive; it does not replace bone density testing or osteoporosis medication when those are indicated.
Sources (2)
- Humphrey MB, Russell L, Danila MI, et al. 2022 American College of Rheumatology Guideline for the Prevention and Treatment of Glucocorticoid-Induced Osteoporosis. Arthritis Care Res (Hoboken). 2023;75(12):2405-2419. PMID 37884467
- Homik J, Suarez-Almazor ME, Shea B, Cranney A, Wells G, Tugwell P. Calcium and vitamin D for corticosteroid-induced osteoporosis. Cochrane Database Syst Rev. 2000;1998(2):CD000952. PMID 10796394
Stack Score
How this pair moves the number.
Effect on the composite score
If both Dexamethasone and Vitamin D2 are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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