From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Pair type
Timing Sensitive
Scope
Supplement × Supplement
Last verified
June 4, 2026
Timing SensitiveModerate evidence
What is happening. Vitamin D3 is fat-soluble and, like fucoxanthin, depends on dietary fat for absorption. Taking them together with a fat-containing meal supports uptake of both. There is no known adverse pharmacologic interaction.
Mechanism. Shared dependence on dietary lipid and micellar incorporation for intestinal absorption of fat-soluble compounds.
Recommendation. Take both with the same fat-containing meal to optimize absorption. No therapeutic conflict expected.
Stack Score
How it moves the number.
Effect on the composite score
If both Fucoxanthin and Vitamin D3 are in the same stack, this pair applies −5 to your Stack Score (per scored timing-sensitive row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
SourcesSources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1Dawson-Hughes B, et al. Dietary fat increases vitamin D-3 absorption. J Acad Nutr Diet. 2015.Needs sourceNo link