NutriStack
Iron Bisglycinate and Pantoprazole, a synergy.
Iron bisglycinate is a chelated iron form whose absorption is less dependent on gastric acid than ferrous sulfate, making it the preferred oral iron for patients on pantoprazole. It tends to cause less GI upset and provides more reliable repletion in PPI-induced hypochlorhydria. It does not fully bypass the hepcidin-mediated suppression PPIs also cause.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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From the interaction database
What the row says.
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At a glance
- Substances
- Iron Bisglycinate and Pantoprazole
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. Iron bisglycinate is a chelated iron form whose absorption is less dependent on gastric acid than ferrous sulfate, making it the preferred oral iron for patients on pantoprazole. It tends to cause less GI upset and provides more reliable repletion in PPI-induced hypochlorhydria. It does not fully bypass the hepcidin-mediated suppression PPIs also cause.
Mechanism. Iron bisglycinate is absorbed intact via amino acid transporters in addition to DMT1, bypassing the gastric acid step needed to ionize inorganic iron salts. Absorption is therefore more pH-tolerant in PPI users.
Recommendation. If you take pantoprazole and need iron supplementation, choose iron bisglycinate over ferrous sulfate. Take 25-30 mg elemental iron daily, ideally on an empty stomach, and recheck ferritin in 3 months.
Sources (2)
- Lam JR, Schneider JL, Quesenberry CP, Corley DA. Proton Pump Inhibitor and Histamine-2 Receptor Antagonist Use and Iron Deficiency. Gastroenterology. 2017;152(4):821-9. PMID 27890768
- Hamano H, Niimura T, Horinouchi Y, et al. Proton pump inhibitors block iron absorption through direct regulation of hepcidin via the aryl hydrocarbon receptor-mediated pathway. Toxicol Lett. 2020;318:86-91. PMID 31669099
Stack Score
How this pair moves the number.
Effect on the composite score
If both Iron Bisglycinate and Pantoprazole are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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