NutriStack
Levetiracetam and Vitamin D3, a synergy.
Levetiracetam has minimal enzyme-inducing effects compared to other anticonvulsants, but long-term use may still modestly reduce vitamin D levels. Monitoring is reasonable.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Levetiracetam and Vitamin D3
- Pair type
- Synergy
- Evidence (highest tier)
- Emerging
- Source citations
- 4 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Emerging evidence
Synergy
What is happening. Levetiracetam has minimal enzyme-inducing effects compared to other anticonvulsants, but long-term use may still modestly reduce vitamin D levels. Monitoring is reasonable.
Mechanism. Levetiracetam does not significantly induce CYP enzymes. Its effect on vitamin D is minimal compared to enzyme-inducing AEDs, but some studies suggest modest bone density reduction with long-term use.
Recommendation. Less vitamin D depletion risk than carbamazepine/phenytoin, but monitoring 25(OH)D levels annually is still recommended for any long-term anticonvulsant.
Sources (4)
- Valsamis HA et al. Antiepileptic drugs and bone metabolism. Nutr Metab (Lond). 2006;3:36. PMID 16956398
- Zhang Y, Fang F, Tang J et al.. Association between vitamin D supplementation and mortality: systematic review and meta-analysis.. BMJ. 2019. PMID 31405892
- Chang MC, Choo YJ. Effects of Whey Protein, Leucine, and Vitamin D Supplementation in Patients with Sarcopenia: A Systematic Review and Meta-Analysis.. Nutrients. 2023. PMID 36771225
- Fiamenghi VI, Mello ED. Vitamin D deficiency in children and adolescents with obesity: a meta-analysis.. Jornal de pediatria. 2021. PMID 33022267
Stack Score
How this pair moves the number.
Effect on the composite score
If both Levetiracetam and Vitamin D3 are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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