Supplement × Prescription·a synergy·Moderate evidence
Pioglitazone increases fracture risk; correcting vitamin D deficiency is relevant to bone-health risk reduction.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
What is happening. Pioglitazone increases fracture risk; correcting vitamin D deficiency is relevant to bone-health risk reduction.
Mechanism. Bone-risk mitigation rather than a direct drug-level interaction.
Recommendation. Check 25-hydroxyvitamin D and address bone health in high-risk patients.
Effect on the composite score
If both Pioglitazone and Vitamin D3 are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
Every claim on this page is cited. PMIDs link straight to PubMed.
Check your full routine
Drop your supplements and prescriptions into NutriStack and it runs every pair at once: every interaction, synergy, timing rule, and contraindication, each linked to its primary source.
NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.
NutriStack