From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Scope
Supplement × Supplement
Last verified
June 4, 2026
CautionInsufficient evidence
What is happening. Both are marketed for hormone-related goals, but wild yam has weak evidence and the combination may encourage unsupervised endocrine self-treatment.
Mechanism. Overlapping hormone-marketing claims without good combined safety or efficacy data.
Recommendation. Avoid using this combination for hormone replacement, fertility, or gender-affirming hormone effects.
Stack Score
How it moves the number.
Effect on the composite score
If both Saw Palmetto and Wild Yam are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
SourcesSources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1Komesaroff PA et al. Wild yam extract menopause trial. Climacteric. 2001.Needs sourceNo link