Supplement × Supplement·a caution·Insufficient evidence

Saw Palmetto + Wild Yam

Caution Insufficient evidence

Both are marketed for hormone-related goals, but wild yam has weak evidence and the combination may encourage unsupervised endocrine self-treatment.

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Substances
Pair type
Caution
Evidence
Insufficient
Source citations
1
Scope
Supplement × Supplement
Last verified
June 4, 2026
CautionInsufficient evidence

What is happening. Both are marketed for hormone-related goals, but wild yam has weak evidence and the combination may encourage unsupervised endocrine self-treatment.

Mechanism. Overlapping hormone-marketing claims without good combined safety or efficacy data.

Recommendation. Avoid using this combination for hormone replacement, fertility, or gender-affirming hormone effects.

Stack Score

How it moves the number.

Effect on the composite score

If both Saw Palmetto and Wild Yam are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1
  • 1Komesaroff PA et al. Wild yam extract menopause trial. Climacteric. 2001.Needs sourceNo link

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