Supplement × Prescription·contraindicated·Moderate evidence
5-HTP can increase serotonin production and may precipitate serotonin syndrome with vilazodone.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
What is happening. 5-HTP can increase serotonin production and may precipitate serotonin syndrome with vilazodone.
Mechanism. Serotonin precursor loading adds to vilazodone-mediated serotonin reuptake inhibition and 5-HT1A activity.
Recommendation. Avoid 5-HTP during vilazodone treatment.
Effect on the composite score
If both 5-HTP and Vilazodone are in the same stack, this pair applies −25 to your Stack Score (per scored contraindication row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
Every claim on this page is cited. PMIDs link straight to PubMed.
Check your full routine
Drop your supplements and prescriptions into NutriStack and it runs every pair at once: every interaction, synergy, timing rule, and contraindication, each linked to its primary source.
NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.
NutriStack