NutriStack
Acetyl-L-Carnitine and Metoprolol, a synergy.
Acetyl-L-carnitine supports cardiac mitochondrial function and modestly lowers diastolic blood pressure. Combined with metoprolol in heart failure or ischemic heart disease, ALCAR may add cardioprotective benefit with minimal interaction risk.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Acetyl-L-Carnitine and Metoprolol
- Pair type
- Synergy
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Emerging evidence
Synergy
What is happening. Acetyl-L-carnitine supports cardiac mitochondrial function and modestly lowers diastolic blood pressure. Combined with metoprolol in heart failure or ischemic heart disease, ALCAR may add cardioprotective benefit with minimal interaction risk.
Mechanism. ALCAR provides acetyl groups for cellular energy and supports beta-oxidation of fatty acids in mitochondria. This helps offset beta-blocker-related fatigue and modestly enhances cardiac efficiency.
Recommendation. Acetyl-L-carnitine 500-1500 mg/day is generally compatible with metoprolol. Discuss with your cardiologist before adding, especially if you have heart failure, and monitor blood pressure when starting.
Sources (2)
- Askarpour M, Hadi A, Dehghani Kari Bozorg A, et al. Effects of L-carnitine supplementation on blood pressure: a systematic review and meta-analysis of randomized controlled trials. J Hum Hypertens. 2019;33(10):725-734. PMID 31481697
- Sharma V, McNeill JH. Parallel effects of β-adrenoceptor blockade on cardiac function and fatty acid oxidation in the diabetic heart. World J Cardiol. 2011;3(10):315-22. PMID 21949571
Stack Score
How this pair moves the number.
Effect on the composite score
If both Acetyl-L-Carnitine and Metoprolol are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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